Diffuse Infiltrative Pontine Glioma (DIPG)
Cristian Rivera was only 6 years old when he lost his battle against DIPG.
Why We Need Your Support
Diffuse Infiltrative Pontine Glioma, or DIPG, is a very rare, incurable brain stem tumor. A pontine glioma occurs in a most delicate area of the brain stem (the "pons"), which controls many critical functions, including breathing. Its location, as well as its infiltrating pattern, means a pontine tumor cannot be safely removed through surgery. Chemotherapy is frequently ineffective, since anti-cancer drugs cannot cross the blood-brain barrier and reach the tumor. Radiation is the most common treatment, but unfortunately the benefit is only temporary and does not provide a cure.
There are about 200 new cases of DIPG diagnosed each year, usually in children under the age of 10. Each of those new cases represents a devastated family struggling to find a cure for their child, but the odds are against them. Survival time for a child diagnosed with DIPG is measured in months, and there has been no significant increase in survival rates over the past three decades.
At the Weill Cornell Pediatric Brain and Spine Center, under the leadership of its Director, Dr. Mark Souweidane, pioneering research is providing hope and the possibility for a cure. Dr. Souweidane recently received approval to launch an innovative clinical trial for DIPG, with a breakthrough approach in which anti-cancer agents are delivered directly to the tumor. Injecting a targeted radio-immunotherapeutic drug directly into the tumor avoids intruding on delicate brain stem tissue, and eliminates the need for medicine to cross the blood-brain barrier. Importantly, this approach also avoids the harmful effects of chemotherapy on the rest of the body. (Find out more about the clinical trial.)
Dr. Souweidane's research into this potentially life-saving procedure, and the clinical trial he's worked so hard to begin, are expensive initiatives. Major funding for cancer research often focuses on more common tumors, leaving children diagnosed with DIPG few options for new and investigative treatments like the one being tested. Thankfully, generous pediatric cancer foundations such as the Dana Foundation, The Cure Starts Now, the Cristian Rivera Foundation, the Beez Foundation, the Matthew Larson Foundation, and St. Baldick's have jumped on board to support Dr. Souweidane's work, enabling his 12-year research and the FDA's approval for his promising first clinical trial.
But the work must continue, as we need to do so much more:
- Design and test other clinical trials using targeted therapy
- Create enhanced delivery systems
- Implement ground-breaking operative equipment
The Weill Cornell Pediatric Brain and Spine Center is a leader in searching for cures for rare pediatric tumors that are so significantly underfunded - or worse, ignored. We have a million-dollar goal - a sum that will allow us to keep up our work on behalf of the many children and their families facing these terrible diagnoses. We are deeply grateful for donations of any size, and thank you in advance for supporting this critical cause.