Weill Cornell's pediatric neuro-oncology group is studying the hormonal and reproductive effects of brain tumors and their treatment. Additional studies are underway on the neuroendocrine aspects of pediatric brain tumors. In collaboration with New York University, studies are focusing on treatment outcomes in children with germ cell tumors. The studies are examining the effects of high-dose chemotherapy with bone marrow reconstitution for pediatric patients with recurrent germ cell tumors; and chemotherapy for patients with newly diagnosed germ cell tumors of the central nervous system. At Weill Cornell, radio-labeled monoclonal antibodies are being used in a study for children with disseminated malignancies of the central nervous system. In addition, studies are being conducted on local delivery systems to treat pediatric tumors.